Sildenafil vs Tadalafil, what are the differences?
Sildenafil and Tadalafil are both effective treatments for erectile dysfunction and belong to the class of PDE5 inhibitors, with Sildenafil known as Viagra and Tadalafil as Cialis. Sildenafil, the first marketed drug for this disorder, is widely used because of its rapid effect, proven effectiveness and because it is flexible to take without a daily dose. Tadalafil is characterized by a longer duration of action, up to 36 hours, and offers a daily dosage option, which can be useful for men who are sexually active on a regular basis. The choice between Sildenafil and Tadalafil often depends on the patient's personal preference, medical history and specific needs, with Sildenafil often being cheaper and preferring occasional use.
Sildenafil vs Tadalafil, what are the differences?
Sildenafil and Tadalafil are the most well-known and effective treatments for erectile dysfunction. Both drugs have proven successful in treating erectile dysfunction, yet they differ in certain areas. Here you can read more about the features, benefits and differences between Sildenafil and Tadalafil and explain why Sildenafil is the most used medication for treating erectile dysfunction.
What is Sildenafil?
Sildenafil is the active substance in Viagra, the brand of erection pills launched by Pfizer in 1998. It is one of the most well-known medications for treating erectile dysfunction. Sildenafil is one of the PDE5 inhibitors that work by widening the blood vessels in the penis and increasing blood flow, making it easier for men to get and maintain an erection during sexual stimulation.
Benefits of Sildenafil:
- Fast effect: Sildenafil usually starts to work within 30 to 60 minutes after ingestion.
- Proven effectiveness: It has been extensively researched and has proven to be an effective treatment for erectile dysfunction.
- Flexibility: Sildenafil can be taken as needed, providing flexibility for sexual activity without a daily dose.
What is Tadalafil?
Tadalafil is the active substance in Cialis, the brand of erection pills launched by Eli Lilly in 2003. Tadalafil is also a PDE5 inhibitor and is used to treat erectile dysfunction. It stands out for its long duration of action and is sometimes called the”weekend pill“named for its ability to remain effective for up to 36 hours after ingestion.
Benefits of Tadalafil:
- Long-term effect: Tadalafil can remain effective for up to 36 hours, allowing for greater spontaneity in sexual activities.
- Daily dosing option: A daily dosing option is available, which may be useful for men who prefer regular sexual activity.
Sildenafil vs Tadalafil
While both medications are effective, the choice often depends on personal preference, medical history, and the patient's specific needs. Sildenafil is the most well-known and used medication for erection problems. In addition, Sildenafil is cheaper than Tadalafil. Tadalafil, on the other hand, may be a good choice for men who may benefit from the longer duration of action. Finally, it can sometimes be the case that if one of the two drugs does not work properly, the other does.
Why is Sildenafil most commonly used for erectile dysfunction?
Despite the benefits of both drugs, Sildenafil remains the most commonly used drug for treating erectile dysfunction. This can be due to several factors:
- Familiarity and trust: Sildenafil was the first drug to enter the market to treat erectile dysfunction, contributing to its fame and trust among patients and healthcare providers.
- Costs: Sildenafil is often cheaper than Tadalafil, especially since it became available as a generic medication.
- Duration of operation: The shorter duration of action of Sildenafil may be preferred for some men and their partners. This is because the shorter duration of action also means that any side effects last for less time.
In short, both Sildenafil and Tadalafil offer valuable options for men dealing with erectile dysfunction. The choice between these two should be made based on personal preferences, lifestyle, and medical needs. At Fellos, we take this into account during your consultation.
Fellos adheres to strict editorial guidelines for sources to ensure the accuracy and timeliness of our content. Our content is based on scientific publications, research from academic institutions, and reputable medical organisations. If you notice an error, please let us know at care@fellos.nl.
This article is intended for informational purposes only and does not constitute medical advice. The information herein is not a substitute for professional medical advice and should never be relied upon. Always discuss the risks and benefits of any treatment with your doctor.
This content was last updated on
26/1/2026

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